The New Science of Fasting: Mechanisms, Clinical Applications, and Biological Aging Paperback – March 18, 2026

What if skipping a meal could reverse your biological clock?Between 2021 and 2026, a quiet revolution unfolded in molecular biology. Researchers discovered that fasting activates cellular mechanisms far beyond weight loss: spermidine-driven autophagy, sirtuin-mediated DNA repair, biological age reversal, and immune reprogramming against cancer.The New Science of Fasting synthesizes over 200 peer-reviewed studies into one evidence-based guide — every claim referenced, every mechanism illustrated, every protocol actionable.What you'll learn:- How spermidine and the eIF5A axis control autophagy — and why fasting fails without them- The 12 Hallmarks of Aging (2023 framework) and how fasting targets all of them- Why the CALERIE and FMD trials proved biological age can be reversed by 2.5 years- The unexpected alliance between GLP-1 receptor agonists and intermittent fasting- How the TREAD trial is testing fasting against Alzheimer's disease- Sex-specific protocols: PCOS, fertility, the HPG axis, and why women respond differently- The truth behind the 2024 AHA headline claiming "91% higher cardiovascular death risk"- Chrononutrition: why eating at 9 PM produces more insulin resistance than the same meal at 9 AM- Precision fasting: comparison tables, fasting mimetics, and biomarker monitoring schedulesFrom the molecular to the practical. From the 12 Hallmarks of Aging to the PRINCESS surgical trial. From cancer immunotherapy to Long COVID viral clearance.Written for clinicians, biohackers, and anyone who wants to understand why controlled nutritional stress may be the most powerful longevity intervention science has ever discovered.A companion volume to La Science du Jeûne Pour les Nuls (2021). Read more